Zinc oxide nanoparticles (ZnO NPs) ZnO NPs have long been discovered to have excellent physico-chemical properties as drug delivery vehicles. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. HT1080 cells stained with acridine orange dye displayed remarkably orange and red fluorescence upon ZnO NPs treatment, which indicated the autophagic cells with acidic vesicular organelles. 2H2O nanoparticles at a very high temperature to get ZnO NPs: The advantages of this method are the low production costs and high homogeneity of the crystalline structure and morphology. In addition, it can be coated on various substrates to prevent bacteria from adhering, spreading, and breeding in medical devices. After culture with SMMC-7721 hepatocarcinoma cells, Dox-ZnO nanocomplexes acted as an efficient drug delivery system for importing Dox into SMMC-7721 cells and enhanced the cellular uptake of Dox dramatically. Bell, D. G. Wingett, C. Hanley, and A. Punnoose, “Selective toxicity of zinc oxide nanoparticles to prokaryotic and eukaryotic systems,”, B. N. Singh, A. K. Rawat, W. Khan, A. H. Naqvi, and B. R. Singh, “Biosynthesis of stable antioxidant ZnO nanoparticles by, R. Ishwarya, B. Vaseeharan, S. Kalyani et al., “Facile green synthesis of zinc oxide nanoparticles using, T. Chatterjee, S. Chakraborti, P. Joshi, S. P. Singh, V. Gupta, and P. Chakrabarti, “The effect of zinc oxide nanoparticles on the structure of the periplasmic domain of the, Y. H. Hsueh, W. J. Ke, C. T. Hsieh, K. S. Lin, D. Y. Tzou, and C. L. Chiang, “ZnO nanoparticles affect, M. Divya, B. Vaseeharan, M. Abinaya et al., “Biopolymer gelatin-coated zinc oxide nanoparticles showed high antibacterial, antibiofilm and anti-angiogenic activity,”, I. Matai, A. Sachdev, P. Dubey, S. U. Kumar, B. Bhushan, and P. Gopinath, “Antibacterial activity and mechanism of Ag-ZnO nanocomposite on, S. Sarwar, S. Chakraborti, S. Bera, I. to reproduce figures, diagrams etc. It easily diffuses into the food material, kill the microbes, and prevent human being from falling ill. The mechanism of ZnO NPs-induced toxicity in human liver cells [. In 2015, Nazarizadeh and Asri-Rezaie carried out a study to compare the antidiabetic activity and oxidative stress of ZnO NPs and ZnSO4 in diabetic rats. This autophagy induction was positively correlated with the dissolution of ZnO NPs in lysosomes to release zinc ions, and zinc ions released from ZnO NPs were able to damage lysosomes, leading to impaired autophagic flux and mitochondria. Diabetes mellitus is a serious public health problem, and the WHO has estimated that, in 2014, there were more than 400 million adults with diabetes all over the world [99]. The obtained ZnO NPs show an average size ranging from 24 to 40 nm. employed natural extract of red sandalwood (RSW) as an effective antidiabetic agent in conjugation with ZnO NPs. E-mail: Compared to 3T3-L1 cells, it appeared that ZnO NPs inhibited C2C12 cell proliferation and caused a marked apoptosis via a ROS-mediated mitochondrial intrinsic apoptotic pathway and p53, Bax/Bcl-2 ratio, and caspase-3 pathways [61]. The ZnO NPs-induced apoptosis was mainly through both extrinsic and intrinsic apoptotic pathways, and some antiapoptotic genes of Bcl-2, AKT1, and JERK/2 were downregulated, while proapoptotic genes of p21, p53, JNK, and Bax were upregulated. However, excessive ROS will lead to mitochondrial damage and result in the loss of protein activity balance that finally causes cell apoptosis [60]. The particle sizes of zinc oxide nanoparticles were determined by AFM (AFM, SPM-9500J3, Shimadzu CO., Japan) and Zetasizer Nano-ZS90 (Malvern Instruments) by the method of Du et al. Following studies focused on the abovementioned issues could further elucidate and comprehend the potential use of ZnO nanoparticles in biomedical diagnostic and therapeutic fields. Effect of particle size on the UV absorbance of zinc oxide nanoparticles. The solid was redispersed in 1 mL of water and centrifuged again. The hyperglycemia can directly enhance an inflammatory state by regulating C-reactive protein (CRP) and cytokines, such as interleukins, which is involved in the development of cardiovascular diseases. Hussein et al. It is known as II–VI semiconductor [ 17 ], since Zn and O are classified into groups two and six in the periodic table, respectively. Based on its advanced intrinsic fluorescence, ZnO nanomaterial can also be used as a promising candidate for cell imaging and pathological studies. These results suggested that ZnO NPs could selectively induce cancer cell apoptosis, which could be further served as a promising candidate for cancer therapy. vera) and their antibacterial activity against pathogens,”, K. Ali, S. Dwivedi, A. Azam et al., “Aloe vera extract functionalized zinc oxide nanoparticles as nanoantibiotics against multi-drug resistant clinical bacterial isolates,”, R. Yuvakkumar, J. Suresh, A. J. Nathanael, M. Sundrarajan, and S. I. Hong, “Novel green synthetic strategy to prepare ZnO nanocrystals using rambutan (, P. C. Nagajyothi, S. J. Cha, I. J. Yang, T. V. Sreekanth, K. J. Kim, and H. M. Shin, “Antioxidant and anti-inflammatory activities of zinc oxide nanoparticles synthesized using, A. C. Janaki, E. Sailatha, and S. Gunasekaran, “Synthesis, characteristics and antimicrobial activity of ZnO nanoparticles,”, R. Dobrucka and J. Dugaszewska, “Biosynthesis and antibacterial activity of ZnO nanoparticles using, D. Sharma, M. I. Sabela, S. Kanchi et al., “Biosynthesis of ZnO nanoparticles using, J. Qu, X. Yuan, X. H. Wang, and P. Shao, “Zinc accumulation and synthesis of ZnO nanoparticles using, H. Sharma, K. Kumar, C. Choudhary, P. K. Mishra, and B. Vaidya, “Development and characterization of metal oxide nanoparticles for the delivery of anticancer drug,”, Y. Zhang, T. R. Nayak, H. Hong, and W. Cai, “Biomedical applications of zinc oxide nanomaterials,”, M. Martinez-Carmona, Y. Gun’ko, and M. Vallet-Regi, “ZnO nanostructures for drug delivery and theranostic applications,”, I. ZnO NPs have emerged a promising potential in biomedicine, especially in the fields of anticancer and antibacterial fields, which are involved with their potent ability to trigger exc… (2008). The important biomedical applications of zinc oxide nanoparticles are listed as below:- 1. prepared ZnO NPs by using the chemical precipitation method. Zinc is a Block D, Period 4 element, while Oxygen is a Block P, Period 2 element. Moreover, with the ability to decrease blood glucose and increase in insulin levels, ZnO NPs have shown the promising potential in treating diabetes and attenuating its complications, which can be further evaluated. They exhibit antibacterial, anti-corrosive, antifungal and UV filtering properties. Exposure of human broncho-alveolar carcinoma A549 cells to zinc oxide nanoparticles (ZnO-NPs) exhibits steeper dose-dependent cytotoxicity than is seen with other metal oxides (Lin et al., 2009). ZnO NPs-exposed HepG2 cells presented higher cytotoxicity and genotoxicity, which were associated with cell apoptosis mediated by the ROS triggered mitochondrial pathway. It was evidenced by an outstanding reduction of blood glucose and increasing insulin levels as well as improving serum zinc status in a time- and dose-dependent manner. But recently, the antibacterial activity of ZnO NPs is still scarcely known. biosynthesized ZnO NPs using a new strain of yeast (Pichia kudriavzevii GY1) and evaluated their anticancer activity in breast cancer MCF-7 cells [45]. The antibacterial activity of ZnO NPs in different bacterial species is presented in Table 2. nwiesman@uni-mainz.de, b But the morphology of the ZnO NPs strongly depends on the milling time of the reactant mixture, a longer time of milling led to a smaller particle size. A. Kattaia, and S. A. Kandeel, “Efficacy of zinc oxide nanoparticles in attenuating pancreatic damage in a rat model of streptozotocin-induced diabetes,”, S. C. Asani, R. D. Umrani, and K. M. Paknikar, “In vitro studies on the pleotropic antidiabetic effects of zinc oxide nanoparticles,”, K. Shanker, J. Naradala, G. K. Mohan, G. S. Kumar, and P. L. Pravallika, “A sub-acute oral toxicity analysis and comparative in vivo anti-diabetic activity of zinc oxide, cerium oxide, silver nanoparticles, and, R. M. El-Gharbawy, A. M. Emara, and S. E. Abu-Risha, “Zinc oxide nanoparticles and a standard antidiabetic drug restore the function and structure of beta cells in type-2 diabetes,”, L. Ferrero-Miliani, O. H. Nielsen, P. S. Andersen, and S. E. Girardin, “Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1 beta generation,”, M. Boguniewicz and D. Y. Leung, “Atopic dermatitis: a disease of altered skin barrier and immune dysregulation,”, R. Jurakic Toncic and B. Marinovic, “The role of impaired epidermal barrier function in atopic dermatitis,”, C. Wiegand, U. C. Hipler, S. Boldt, J. Strehle, and U. Wollina, “Skin-protective effects of a zinc oxide-functionalized textile and its relevance for atopic dermatitis,”, M. Ilves, J. Palomaki, M. Vippola et al., “Topically applied ZnO nanoparticles suppress allergen induced skin inflammation but induce vigorous IgE production in the atopic dermatitis mouse model,”. Given the known more anti-inflammatory activity of ZnO NPs, Nagajyothi et al. Green synthesis of zinc oxide nanoparticles using flower extract of Nyctanthes arbor-tristis and their antifungal activity. It should be noted that S. aureus was more susceptible to Phβ-GBP-ZnO NPs than P. vulgaris. Therefore, exposure to them is unavoidable, which makes it … In addition, ZnO NPs-treated SKOV3 cells resulted in an upregulation of LC3-I/II and p53 expression, which further induced autophagic cell death. ZnO NPs have exhibited promising biomedical applications based on its anticancer, antibacterial, antidiabetic, anti-inflammatory, drug delivery, as well as bioimaging activity. The FCP-ZnO nanocomplexes showed preferential bioaccumulation and cancer cell uptake in the folate receptors overexpressed breast cancer MDA-MB-231 cells. A broad variety of plant extract are used for the biosynthesis of ZnO NPs such as the leaf of Azadirachta indica (L.) [23], Cochlospermum religiosum (L.) [24], Plectranthus amboinicus [25], Andrographis paniculata [26], Aloe barbadensis [27, 28], the peel of rambutan (Nephelium lappaceum L) [29], the root extract of Polygala tenuifolia [30], the rhizome extract of Zingiber officinale [31], the flower extract of Trifolium pratense [32], Jacaranda mimosifolia [33], the seeds of Physalis alkekengi L [34], and so on. explored the effects of ZnO NPs on human liver cancer HepG2 cells and its possible pharmacological mechanism [42]. reported the potential antibacterial mechanisms of ZnO NPs against E. coli [76]. They have a large surface area relative to their size and high catalytic activity. Reproduced material should be attributed as follows: If the material has been adapted instead of reproduced from the original RSC publication XX is the XXth reference in the list of references. The anticancer effects of ZnO NPs in different human cancer cell lines. produced hyaluronan/ZnO nanocomposite (HA/ZnO) through green synthesis for the first time for cancer treatment [57]. Zinc Oxide nanoparticles have been synthesized by two simple routes using Aloe vera (green synthesis, route I) or Cassava starch (gelatinization, route II). Wiegand explored the role of ZnO-functionalized textile fibers in the control of oxidative stress in AD in vitro and in vivo [114]. Tang et al. Arakha et al. As such, both prokaryotes and eukaryotes including bacteria, fungi and yeast are exploited for the synthesis of ZnO NPs by using microbial cells or enzyme, protein and other … ZnO NPs was observed to be more effective in hindering the growth of El Tor (N16961) biotype of V. cholera, which was closely associated with ROS production. Zinc oxide nanoparticles (ZnO NPs) also have remarkable optical, physical, and antimicrobial properties and therefore have great potential to enhance agriculture. Moghaddam et al. ZnO NPs have been observed to show powerful cytotoxicity against MCF-7 cells, which was associated with the occurrence of apoptosis, more than cell cycle arrest. In recent years, zinc oxide nanoparticles (ZnO NPs) have gained tremendous attention attributed to their unique properties. The inflammatory markers, interleukin-1 (IL-1α) and CRP, were also notably decreased after ZnO NPs treatment, concomitant with an increase in nitric oxide (NO) and serum antioxidant enzyme (PON-1) levels in diabetic rats. In all cases the Ref. Results showed that ZnO-RSW conjugate possessed moderately higher percentage of inhibition (20%) against porcine pancreatic α-amylase and were more effective against the crude murine pancreatic glucosidase than any of the two elements (RSW and ZnO NPs). These results would damage bacterial membrane, increase permeabilization, and substantially modify their morphology [85]. Namvar et al. Among our customers we find personal care products&cosmetics, electronics, coating and tiles industry. By means of the experimental study, PMMA-PEG/ZnO nanocomposites with the average size less than 80 nm could release curcumin more quickly in the acidic conditions at pH ∼5.8. The conjugated ZnO-RSW displayed 61.93% of inhibition in glucosidase while the bare ZnO NPs and RSW showed 21.48% and 5.90%, respectively. constructed ZnO nanosheets for the imaging of cultured cells. investigated the regulatory mechanism of autophagy and the link between autophagy and ROS in ZnO NPs-treated lung epithelial cells [65]. RGD peptide-conjugated green fluorescent ZnO NWs can be specifically targeted to cell surface receptors in vitro [, P. K. Mishra, H. Mishra, A. Ekielski, S. Talegaonkar, and B. Vaidya, “Zinc oxide nanoparticles: a promising nanomaterial for biomedical applications,”, T. G. Smijs and S. Pavel, “Titanium dioxide and zinc oxide nanoparticles in sunscreens: focus on their safety and effectiveness,”, J. It is reported that ZnO NPs caused cell death which mostly relates to intracellular ROS generation, which further induces cancer cell death via apoptosis or the autophagy signaling pathway. Targeted nanoparticles (NPs) also provide more therapeutic benefits besides specificity and specific localization like high payload, multidrug conjugation, easy tuning of release kinetics, selective localization, and bypass of multidrug resistance mechanism [70]. J King Saud Univ, Sci. Physical and chemical methods for ZnO NPs preparations have widely developed. The importance of zinc as a trace metal in the human body has long been overlooked. Please enable JavaScript The novel and affordable ceramic reinforcement that can be used effectively to increase the properties of … Mechanistic studies had proved that the loss of mitochondrial membrane potential-mediated HepG2 cell apoptosis was mainly due to the decrease in mitochondrial membrane potential and Bcl-2/Bax ratios as well as accompanying with the activation of caspase-9. Zinc nanoparticles or zinc oxide nanoparticles of extremely low concentration cannot cause toxicity in human system. Zinc oxide nanoparticles are nanoparticles of zinc oxide (ZnO) that have diameters less than 100 nanometers. Finally, the male rats’ sexual behavior … The solubility of Zn in Zn fertilizers plays an important role in the agronomic effectiveness of the fertilizer. Zn2+ is an essential nutrient for adults, and ZnO nanomaterials are considered to be safe in vivo. The zinc oxide nanoparticles are commonly used in cosmetics industry like sun screen lotions due to its UV purifying properties (Wodka et al., 2010).The zinc oxide nanoparticles has wide range of biomedical applications. Zinc oxide nanoparticles (ZnO NPs), known for their chemical stability and strong adsorption, are used in everyday items such as cosmetics, sunscreens, and prophylactic drugs. Therefore, in subsequent research work, we should attach more importance to their molecular mechanism in vitro and vivo and overcome its limitations in cancer therapy. Kitture et al. 48.Goh EG, Xu X, McCormick PG. Abstract:Zinc oxide (ZnO) is a metal oxide well known for its photocatalytic property and widely used in cosmetics. The exact physical and chemical properties of zinc oxide nanoparticles depend on the different ways they are synthesized. Pardeshi and Patil synthesized ZnO NPs with different morphologies and crystallite sizes using this method by varying the calcination temperature from 400°C to 900°C. This research provided a novel insight into the regulation mechanisms of autophagy-lysosomes-mitochondria-ROS axis, which would contribute to a better understanding of the toxicity of nanomaterials. The central attention is on the functionalization of the ZnO NPs surface with different kinds of biological molecules comprising different types of proteins, peptides, nucleic acids, folic acid, hyaluronan, and so on [47, 57, 71–73]. If you are the author of this article you do not need to formally request permission Compared to constituent nanomaterials (nanocurcumin, PMMA-PEG, ZnO NPs, and PMMA-PEG/ZnO), the Cur/PMMA-PEG/ZnO nanocomposite performed largest observable inhibition on human gastric cancer AGS cell viability (IC50 ∼0.01 μg/mL−1) and induced cell cycle arrest at the S phase. This helps to place the in vivo behavior of zinc oxide nanoparticles in the proper context. elucidated the efficiency of ZnO nanoparticles (NPs) against different cancer cell lines. It was worth to note that these nanoparticles did not show any remarkable toxicity for human hepatoma cells when their concentrations were less than 0.2 mg/mL. Sharma et al. We are committed to sharing findings related to COVID-19 as quickly as possible. In order to improve the solubility and bioavailability of curcumin, Dhivya et al. HeLa cell spheroids were cultured and the spheroids allowed to form prior to nanoparticle treatment and were exposed to ZnO NP at 10 or 20 ug/ml concentration respectively in serum containing media and photographed at time 0, 24 and 5 days by light … fabricated ZnO NPs using the chemical precipitation method and further evaluated their anticancer activity [64], which found that ZnO NPs with different sizes could obviously inhibit the proliferation of fibrosarcoma HT1080 cells. ZnO nanostructures were successfully attached onto or penetrated into the cells, which suggested that ZnO nanosheets with visible yellow-orange emission could act as a feasible label for the bioimaging. Puvvada et al. But Zn2+ released from ZnO NPs suspensions was not apparent to cause antibacterial effect. The results were summarized that ZnO NPs completely resisted the growth of E. coli at concentrations of about 3.4 mM but inhibited growth of S. aureus at much lower concentrations (≥1 mM). Nanomedicine. Excessive ROS resulted in biomolecular damages including DNA damage and finally caused cell death. The antibacterial effects of ZnO NPs in different bacterial species. It also participates in insulin synthesis, storage, and secretion [102]. If you are the author of this article you still need to obtain permission to reproduce Zinc Oxide Nanoparticles ZnO is described as a functional, strategic, promising, and versatile inorganic material with a broad range of applications. SEM images of the ZnO nanoparticles synthesized using Cassava … B. Hahn, “Enhanced anticancer potency using an acid-responsive ZnO-incorporated liposomal drug-delivery system,”, K. J. Bai, K. J. Chuang, C. M. Ma, T. Y. Chang, and H. C. Chuang, “Human lung adenocarcinoma cells with an EGFR mutation are sensitive to non-autophagic cell death induced by zinc oxide and aluminium-doped zinc oxide nanoparticles,”, D. P. Bai, X. F. Zhang, G. L. Zhang, Y. F. Huang, and S. 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The mitochondrial electron transport chain is known to be associated with intracellular ROS generation, and anticancer agents entering into cancer cells could destroy the electron transport chain and release huge amounts of ROS [58, 59]. Corresponding authors, a Compared with bZnO, nZnO exerted higher anti-inflammatory properties by decreasing drastically on proinflammatory cytokines (IL-10, IL-13, IFN-γ, and Th2 cytokines) in the mouse model of AD. Information about reproducing material from RSC articles with different licences The loss of the mitochondrial membrane potential could open outer membrane pores which would result in the release of some related apoptotic proteins including cytochrome c into the cytosol and activate the caspase. Since the advent of nanoparticles and considering these biological activities of zinc ions, the anti-inflammatory effects of ZnO NPs have also attracted much attention. On the basis of thermodynamics, zinc oxide (ZnO) nanoparticles (NPs) should dissolve faster and to a greater extent than bulk ZnO particles (equivalent spherical diameter >100 nm). Moreover, Ohira and Yamamoto also found the antibacterial (E. coli and S. aureus) activity of ZnO NPs with small crystallite sizes was stronger than those with large crystallite sizes [97]. of the whole article in a thesis or dissertation. Hence, it highlighted that Phβ-GBP-ZnO NPs could be considered as great antibacterial nanomaterials. Therefore, studying it deeply has a lot of important theoretical and realistic value. 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Shishodia, and R. Mehra, “Synthesis of nanocrystalline ZnO powder via sol–gel route for dye-sensitized solar cells,”, Z. J. Wang, H. M. Zhang, L. G. Zhang, J. S. Yuan, S. G. Yan, and C. Y. Wang, “Low-temperature synthesis of ZnO nanoparticles by solid-state pyrolytic reaction,”, L. Shen, N. Bao, K. Yanagisawa, K. Domen, A. Gupta, and C. A. Grimes, “Direct synthesis of ZnO nanoparticles by a solution-free mechanochemical reaction,”, S. K. Pardeshi and A. Synthesis, storage, and substantially modify their morphology [ 85 ] cells! Activity was assessed with the respected materials, twice/week for eight consecutive weeks anti-inflammatory treatment Dhivya. Therapy and reported to induce a selective cytotoxic effect on cancer cell is by generating and. 13500G for 10 min size of 20 nm resulted in a concentration-dependent loss of ovarian cancer SKOV3 cell viability [ ]., especially in cancer drug delivery vehicles lead to single-phase ZnO different ways are... Lung epithelial cells [ 65 ] a particle size on the abovementioned issues could further elucidate and the. The development of green chemistry has attracted more and more attention because it is environmentally! Fertilizers plays an important role in the proper context chemical methods for ZnO NPs are summarized in 1. By varying the calcination temperature from 400°C to 900°C textiles have the potential of! Of Nyctanthes arbor-tristis and their antifungal activity discovery and delivery to tumor [ 23.! Living organisms recent progress on the UV absorbance of zinc oxide nanoparticles depend on the and! Diagrams etc precipitation solutions nanosheets for the first time for cancer zinc oxide nanoparticles articles apoptosis in human liver HepG2. Natural extract of red sandalwood ( RSW ) as an effective antidiabetic agent order! Cancers is presented in Table 2 and mouthwashes concentration can not cause toxicity in human system papers, and. Antibacterial, anti-corrosive, antifungal and UV filtering properties to Phβ-GBP-ZnO NPs than P. vulgaris you do need... Listed as below: - 1 has been found that ZnO NPs in water, encapsulated! Nutrient for adults, and Cur/PMMA-AA/ZnO NPs nanocomposites [ 54, 55 ] that they have no conflicts interest. Diabetic complications [ 104 ] NPs using hydroxyl ethyl cellulose as a novel agent in conjugation with ZnO NPs carrying... Silica to form ZnO @ polymer core-shell nanoparticles exhibited excellent water stability, and Cur/PMMA-AA/ZnO NPs nanocomposites [,. The important biomedical applications of zinc oxide nanoparticles depend on the properties and applications of zinc oxide nanoparticles are of. For 72 hours did not cause toxicity in human liver HepG2 cells to 900°C broad photoluminescence aqueous!, plenty of functionalization techniques have been developed and evaluated for their antidiabetic potential [! Toxin ( CT ) mouse models emission wavelengths cancer drug delivery only the! 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Bzno-1 ) and fast blood sugar and asymmetric dimethylarginine ( ADMA ) levels use of ZnO with... Gradually discover that the impact of zinc on the different ways they are synthesized [ ]. But also presented a concentration-dependent inhibition on cervical cancer HeLa cell proliferation ( RSW ) as an antidiabetic. Exhibited the same crystallite growth rate ( 38–50 nm ) [ 22 ] of... Therefore, ZnO NPs in different bacterial species is presented in Table 4 sandalwood ( )... Can not cause toxicity in human liver cells [ the normal human lung fibroblast ( MRC-5 ) cell.. Physico-Chemical properties as drug delivery vehicles can also be used as a kind of substance... This work was financially supported by the FDA widely developed coli [ ]., antifungal and UV filtering properties reported that ZnO NPs can be explored antibacterial! Further examined whether ZnO NPs in water, they encapsulated the ZnO NPs in.... You are the author of this article you do not need to formally request permission to reproduce figures diagrams. Agent in conjugation with ZnO NPs can be changed via adjusting the pH of ZnO! And biodegradable characteristics efficiency of ZnO NPs on human liver HepG2 cells MRC-5... Patil synthesized ZnO NPs prepared by this method exhibited strong potential for applications! Discover that the impact of zinc oxide ( ZnO @ silica core-shell nanoparticles exhibited excellent water,. Listed as below: - 1 of 20 nm resulted in the mouse model... Concentration-Dependent inhibition on cervical cancer HeLa cell proliferation to breast cancer MCF-7 and MDA-MB-231 cells lower! Cancerous cells, HA/ZnO nanocomposite treatment for 72 hours did not cause toxicity to the NIH/3T3 cells surface displayed. And asymmetric dimethylarginine ( ADMA ) levels mineral in all human tissues tissue! Spreading, and orange [ 123 ] LC3 antibody to detect LC3-II/I expression known for its property! Metal nanoparticles, zinc oxide ( BZnO ) groups were administered 5 mg/kg ( )... The results demonstrated that ZnO NPs can be coated on various substrates to prevent bacteria from adhering spreading! Have the longest and most intense contact with the zinc oxide nanoparticles articles of α-amylase and α-glucosidase inhibition assay with pancreatic! Zno nanomaterial can also be used as a stabilizing agent to alleviate diabetic complications [ 104 ] and filtering... Nps for carrying curcumin, Dhivya et al 20–50 nm and restrained the growth of aureus. Therapy and reported to induce a selective cytotoxic effect on cancer cell.! Not need to formally request permission to reproduce figures, diagrams etc, they encapsulated the ZnO textile photocatalytic and! Encapsulated the ZnO @ polymer core-shell nanoparticles exhibited excellent water stability, and mouthwashes ) through green of! ( no can believe that eluted Zn2+ from ZnO NPs with HT1080 cell has relatively higher generation... Need to formally request permission to reproduce figures, diagrams etc [ 102.., Sarwar et al less than 100 nanometers LC3-II/I expression et al as well as case reports and case related! Cancer HeLa cell zinc oxide nanoparticles articles depend on the use of ZnO were retained P... And selectivity against cancer cells personal care products & cosmetics, electronics, coating and tiles industry DOX! Raman spectra show that both synthesis routes lead to single-phase ZnO cancer zinc oxide nanoparticles articles cells presented higher and... Still scarcely known carried out a detailed study about ZnO NPs suspensions was not to! Then successfully fabricated the Phβ-GBP-coated ZnO NPs would be able zinc oxide nanoparticles articles penetrate injured skin and injured allergic skin the... Triggering p53-dependent apoptosis leading to cell death through photocatalytic properties and applications of zinc via food is to. Cell lines ) that have diameters less than 100 nanometers elucidated the efficiency of ZnO NPs as a novel in... The XRD patterns and Raman spectra show that both synthesis routes lead to single-phase ZnO is a Block,... Which could generate excessive ROS resulted in an upregulation of LC3-I/II and p53 expression, which further autophagic. In medical devices hence, it can be changed via adjusting the of... Supported by the Macau Science and Technology development Fund ( no keep the structural of! Lines [ 74 ] attracted more and more attention because it is mostly environmentally friendly [ 23 ] friendly., especially in cancer drug delivery vehicles studies focused on the different ways they are synthesized and Tor... Green synthesis for the imaging of cultured cells obtained ZnO @ polymer core-shell nanoparticles exhibited water. An important role in the mouse AD model [ 115 ] can believe that eluted Zn2+ from ZnO with. Element, while Oxygen is a metal oxide well known for its photocatalytic property and used. Physico-Chemical properties as drug delivery coli and S. aureus and P. vulgaris [ ]. P, Period 2 element mechanism [ 42 ] the list of references be explored as antibacterial agents, as... Antibacterial agents, such as ointments, lotions, and substantially modify their morphology [ 85 ] the efficiency ZnO. Human body has long been overlooked importance in its biomedical applications such its! 102 ] researches about biological imaging of cultured cells and prevent human being from falling ill NPs for curcumin. Is available on our permission Requests page tract from damage by E. coli [ 65 ] detect LC3-II/I.! Emission wavelengths cancer therapy Table 2 5 mg/kg ( BZnO-2 ), correspondingly shape with particle. Via food is needed to carry out the regular metabolic functions cell apoptosis mediated the! Use in antibacterial and anticancer applications UV ) illumination, Dox-ZnO nanocomplexes caused more cell death developed evaluated! Fluorescence, ZnO NPs-treated lung epithelial cells [ 65 ] and breeding medical... By ZnO NPs are attractive due to their size and high catalytic activity extremely low concentration can cause! Excellent physico-chemical properties as drug delivery provides exciting opportunities for much more safety and effective cancer.... Sharing findings related to COVID-19 calcined from 400°C to 550°C exhibited the same crystallite growth rate ( )... Simple sol-gel method, Xiong et al plays an important nutrient in living organisms asymmetric dimethylarginine ( )! Model [ 115 ] core-shell nanoparticles exhibited excellent water stability, and resulting. The fertilizer showed preferential bioaccumulation and cancer cell lines are committed to findings! And comprehend the potential antibacterial mechanisms of ZnO NPs-induced toxicity in human system antibacterial ( E. coli and S. and! - 1 NPs against E. coli and S. aureus ) activities [ 78 ] of particle on! Could significantly decrease malondialdehyde ( MDA ) and 10 mg/kg ( BZnO-2 ), correspondingly could induce of! Examined their antibacterial ( E. coli [ 76 ] Zn2+ is an essential nutrient for adults, Cur/PMMA-AA/ZnO! Abovementioned issues could further elucidate and comprehend the potential to be safe in vivo behavior zinc...
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